College Football. College Football Odds: Opening Betting Lines for Week 4 1: 47 | College Football 1 Alabama () at Vanderbilt, No. nfl | Sun 9/24 PM CFB Odds - BOOKMAKER. ODDS POWERED BY .. College Football Week 4 Expert Picks: Wiseguys All Over Michigan, Clemson. Here are the early spreads for the biggest games of next weekend. games and 7- 1 ATS over its last eight per the OddsShark College Football. Betting on Week 1 of the college football season opened Thursday at the South Point sports book in Las Vegas. While there are four. The betting lines for college football's first big weekend are out, with point spreads ranging from the close contests expected in Alabama-Florida. The meeting between the Crimson Tide and Seminoles leads the Week 1 betting card.